שכיחות קרטקונוס במשפחה

Introduction:

Keratoconus (KC) is a thinning of the cornea usually in the inferior-temporal region, which leads to a protrusion in the cornea, high myopia and irregular astigmatism (Romero-Jiménez et al., 2010). The incidence of KC in the general population has been estimated to vary between 2 and 23 per 10,000 (Wagner et al., 2007, 2010;Rabinowitz, 1998; Kennedy et al., 2003). Although the etiology of KC is unknown, a genetic connection has been suggested (Wang et al, 2000). In this study, we aim to determine the risk of KC in family members of the proband patients and to collect information on the environmental risks factors for KC.

Methods:

Autorefraction and autokeratometry (L-80), corneal topography and pachymetry (Sirius), visual acuity (Snellen), slit lamp biomiscroscopy and retinoscopy were done on family members. A diagnosis of KC was based on abnormal topography and at least on one clinical sign (Rabinowitz, 2003).

Results:

3 families, 11 subjects were examined. Parameters of healthy subjects (n=8) were: Visual Acuity of 6/6.66, refraction and cylinder range of -1.00 ± 0.71 (range -2.25D to Plano), and-0.47 ± 0.38 (range -0.88 to -0.00D), K steep and K flat readings of 7.70±0.13 mm (7.47 to 7.96) and 7.83± 0.14 mm (7.63 to 8.10), central corneal thickness of 539.93 ± 15.49µm (range: 512 to 575µm). The study is still in progress.

Conclusions:

The study is still on progress.

מרכזת המחקר לתואר ראשון - ד"ר ליאת שניאור